Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of combined application of apatinib and perioperative quality nursing based on Oremâ€™s self-care theory in patients undergoing cholangiocarcinoma resection

Xinsheng Li¹, Weina Zhong², Limin Zhang¹

¹Department of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China; ²Department of Nephrology, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China.

For correspondence:- Limin Zhang Email: yangai45480898814@163.com

Accepted: 28 October 2022 Published: 30 November 2022

Citation: Li X, Zhong W, Zhang L. Effect of combined application of apatinib and perioperative quality nursing based on Oremâ€™s self-care theory in patients undergoing cholangiocarcinoma resection. Trop J Pharm Res 2022; 21(11):2459-2465 doi: 10.4314/tjpr.v21i11.27

© 2022 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of application of perioperative quality nursing based on Orem’s self-care theory, in combination with apatinib in patients who underwent cholangiocarcinoma resection.

Methods: Ninety patients who underwent cholangiocarcinoma resection in The Fourth Hospital of Hebei Medical University from Feb. 2019 to Feb. 2020 were assigned to control group (CG) and study group (SG) based on their order of admission, with 45 patients in each group. Conventional nursing in combination with conventional treatment was applied to CG, while perioperative quality nursing based on Orem’s self-care theory was used in combination with apatinib therapy in SG patients. Comparison was made between CG and SG regarding clinical efficacy, self-care ability and quality of life (QoL, based on QLQ-C30 score).

Results: Disease control rate (DCR) and Barthel index (BI) score were higher in SG than in CG (p < 0.05). After treatment, QoL score was higher in SG than in CG (p < 0.001).

Conclusion: Implementation of perioperative quality nursing along with apatinib therapy in patients undergoing cholangiocarcinoma resection improves their QoL and enhances their self-care ability. Thus, this treatment modality has high utility and treatment potential.

Keywords: Oremâ€™s self-care theory, Apatinib, Cholangiocarcinoma resection, Quality of life